There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval, integration and analysis of data, we have developed the Saliva Ontology and SDxMart. This article reviews the informatics advances in saliva (...) diagnostics made possible by the Saliva Ontology and SDxMart. (shrink)

One way to interpret the work of Joshua Greene (2001; 2008; 2014) is that the wave of empirical research into moral decision-making is a way for us to become more confident in our ability to gain moral knowledge. We argue that empirical research into moral judgment has shown (both survey-based and brain-based) that the grounds of moral judgment are opaque on several dimensions. We argue that we cannot firmly grasp what the morally relevant/irrelevant features of a decision context are, understand (...) which cognitive system responds to said features, and further know that we are actually basing our judgment upon what we take to be the morally relevant features. That is, we argue that moral judgment is very much like other kinds of judgment: Deeply influenced by facts about the decision-context and the decision-maker. However, if moral judgment is merely the exercise of our general judgment making faculty, we shouldn’t be surprised by this result. We conclude by considering what this means for our practice of making moral judgments. (shrink)

An experiment was performed to test the hypothesis that people sometimes take physical actions to make themselves more effective problem solvers. The task was to generate all possible words that could be formed from seven Scrabble letters. In one condition, participants could use their hands to manipulate the letters, and in another condition, they could not. Results show that more words were generated with physical manipulation than without. However, an interaction was obtained between the physical manipulation conditions and the specific (...) letter sets chosen, indicating that physical manipulation helps more for generating words in some circumstances than in others. Overall, our findings can be explained in terms of an interactive search process in which external, physical activity effectively complements internal, cognitive activity. Within this framework, the interaction can be explained in terms of the relative difficulty of generating words from the letters given in the different sets. (shrink)

There is growing interest in the use of technology to enhance the tracking and quality of clinical information available for patients in disaster settings. This paper describes the design and evaluation of the Wireless Internet Information System for Medical Response in Disasters (WIISARD).

Dramatic advances in 3D Web technologies have recently led to widespread development of virtual world Web browsers and 3D content. A natural question is whether 3D thumbnails can be used to find one’s way about such 3D content the way that text and 2D thumbnail images are used to navigate 2D Web content. We have conducted an empirical experiment that shows interactive 3D thumbnails, which we call worldlets, improve travelers’ landmark knowledge and expedite wayfinding in virtual environments.

Virtual environment landmarks are essential in wayfinding: they anchor routes through a region and provide memorable destinations to return to later. Current virtual environment browsers provide user interface menus that characterize available travel destinations via landmark textual descriptions or thumbnail images. Such characterizations lack the depth cues and context needed to reliably recognize 3D landmarks. This paper introduces a new user interface affordance that captures a 3D representation of a virtual environment landmark into a 3D thumbnail, called a worldlet. Each (...) worldlet is a miniature virtual world fragment that may be interactively viewed in 3D, enabling a traveler to gain first-person experience with a travel destination. In a pilot student conducted to compare textual, image, and worldlet landmark representations within a wayfinding task, worldlet use significantly reduced the overall travel time and distance traversed, virtually eliminating unnecessary backtracking. (shrink)

Graduates' employability indicates the excellent education and relevant preparation they obtained from their respective degrees. Tracer studies have enabled higher education institutions to profile their graduates while also reflecting on the quality of education they provide. With the foregoing, a tracer study determined the demographic and academic profile of teacher education graduates from 2017 to 2020 in a state university in the West Philippines. It also ascertained the advanced studies they attended after college, their employment data, the relevance of college (...) preparation with their current employment, difficulties they encountered while securing employment and in their present job, and recommendations to strengthen the teacher education program. The study utilized a descriptive survey research design with 80 non-random samples chosen based on availability. The survey was based on the Philippine Commission on Higher Education with modifications elucidated from previous studies. Results showed that graduates took the teacher education program with a strong passion for the teaching profession. More graduates received honors and awards, passed the licensure examinations for teachers, attended advanced studies for professional development, and are employable. Besides, the graduates’ college preparation is relevant to their current employment. Further, difficulties and problems encountered and recommendations to strengthen the teacher education program were noted. These findings may serve as a baseline for curriculum review and give suggestions for future tracer studies. (shrink)

Debate about legal and policy reform has been haunted by a pernicious confusion about human nature, the idea that it is a set of rigid dispositions, today generally conceived as genetic, that is manifested the same way in all circumstances. Opponents of egalitarian alternatives argue that we cannot depart far from the status quo because human nature stands in the way. Advocates of such reforms too often deny the existence of human nature because, sharing this conception, they think it would (...) prevent changes they deem desirable. Both views rest on deep errors about what it is to have a nature and how genetics works. Human nature, like the nature of anything else, is a set of potentials to behave certain ways in given environments, not a nonsocial genetic something that inevitably produces the same result in any environment. To say that existing inequalities, are due to our genes, inalterable because heritable, ignores that genetic propensities may be differently manifested in different environments. Heritability has meaning only relative to an environment and a population and implies nothing about inevitability. A better sort of inegalitarian argument is that a proposed reform, given our nature, would be too costly even if possible. However, this sort of argument is too rarely supported by evidence and generally ignores the costs of existing inequalities. But egalitarians err in supposing that, if behavior is unconstrained by biology, the status quo is easily alterable. The environment may be extremely hard to change. Legal and policy debate should adopt a correct understanding of human nature as a set of propensities and ask of any proposed reform agreed to be otherwise desirable what and how alterable are its causes, genetic, environmental, or more accurately both. (shrink)

The self-fashioning of French Newtonianism Content Type Journal Article DOI 10.1007/s11016-010-9511-3 Authors Charles T. Wolfe, Unit for History and Philosophy of Science, University of Sydney, Sydney, NSW 2006, Australia David Gilad, Unit for History and Philosophy of Science, University of Sydney, Sydney, NSW 2006, Australia Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

Musical works change. Bruckner revised his Eighth Symphony. Ella Fitzgerald and many other artists have made it acceptable to sing the jazz standard “All the Things You Are” without its original verse. If we accept that musical works genuinely change in these ways, a puzzle arises: why can’t I change Bruckner’s Eighth Symphony? More generally, why are some individuals in a privileged position when it comes to changing musical works and other artifacts, such as novels, films, and games? I give (...) a view of musical works that helps to answer these questions. Musical works, on this view, are created abstract objects with no parts. The paradigmatic changes that musical works undergo are socially determined normative changes in how they should be performed. Due to contingent social practices, Bruckner, but not I, can change how his symphony should be performed. Were social practices radically different, I would be able to change his symphony. This view extends to abstract artifacts beyond music, including novels, films, words, games, and corporations. (shrink)

We start by presenting three different views that jointly imply that every person has many conscious beings in their immediate vicinity, and that the number greatly varies from person to person. We then present and assess an argument to the conclusion that how confident someone should be in these views should sensitively depend on how massive they happen to be. According to the argument, sometimes irreducibly de se observations can be powerful evidence for or against believing in metaphysical theories.

Is the family subject to principles of justice? In "A Theory of Justice", John Rawls includes the (monogamous) family along with the market and the government as among the, "basic institutions of society", to which principles of justice apply. Justice, he famously insists, is primary in politics as truth is in science: the only excuse for tolerating injustice is that no lesser injustice is possible. The point of the present paper is that Rawls doesn't actually mean this. When it comes (...) to the family, and in particular its impact on fair equal opportunity, (the first part of the Difference Principle, Rawls' second principle of justice), he abandons the priority of justice. I also argue that he is right to do so. -/- The central argument is simple. As Rawls admits, what family one is raised by profoundly affects one's life chances: a child raised by a family has far greater life chances on every dimension than one raised in a poorer family that may lack books, education, and time to give the child attention. But the prevailing family arrangements in the industrialized West, assigning children to be raised by their biological parents, is guaranteed to perpetuate this injustice. While Rawls says an unjust institution in the basic structure of society, in which he includes the family, must be, "reformed or abolished," he refrains from calling for the reform or abolition of the family. We must simply work around it to compensate for the injustices he admits it involves. And this despite the fact that alternative arrangements involving communal child-rearing (Plato) or assigning children to those best qualified to raise them (Rousseau) are common in the philosophical literature. Moreover, the practice of having children raised by their biological parents is a relatively recent one, at least in the West, where, before the late 18th century, fostering-out or apprenticeship arrangements were normal and expected for both rich and poor for centuries. -/- Much of the paper is devoted to fine-grained textual analysis of Rawls' attempts to avoid the devastating implications of this argument for his theory of justice -- much of which are stated only in the original edition of "A Theory of Justice" and simply deleted, without substitution by anything better, in the second edition. In the end, Rawls has no way out. He cannot keep the priority of justice, fair equality of opportunity, and the monogamous family in which children are raised by their biological parents. As he admits, these are mutually inconsistent. -/- In the final part of the paper, I argue that Rawls should give up on the priority of justice. While child-rearing by the biological parents is a historical anomaly, in the real modern world it would be politically unfeasible to institute Platonic, Rousseauean, or similar legislation that purportedly assigned children to those best able to raise them, regardless of biological relationship. Since Rawls is committed to principles of political stability and feasibility, as he should be, and since ought implies can, such proposals are off the table. I concur with Rawls that we must work around this injustice, even those there are more just arrangements available in principle. But the cost of this -- less high than Rawls suggests -- is abandoning the principle of the priority of justice. Justice is one of a number of considerations that we must or may balance in deciding on the best attainable social relations. It is not a trump. However, this comes a great cost for Rawls: he must also abandon the lexical ordering of principles of justice or, in general, right or good principles of social order, in favor of the messy intuitionist balancing that his theory is designed to avoid. -/- One feature of the paper that is worth independent attention is a discussion of Marx's rejection of justice in the Critique of the Gotha Program, which I explicate, and urge, without adopting it, that it has a great deal more force than is widely understood. (shrink)

This thesis brings together two concerns. The first is the nature of inference—what it is to infer—where inference is understood as a distinctive kind of conscious and self-conscious occurrence. The second concern is the possibility of doxastic agency. To be capable of doxastic agency is to be such that one is capable of directly exercising agency over one’s beliefs. It is to be capable of exercising agency over one’s beliefs in a way which does not amount to mere self-manipulation. Subjects (...) who can exercise doxastic agency can settle questions for themselves. A challenge to the possibility of doxastic agency stems from the fact that we cannot believe or come to believe “at will”, where this in turn seems to be so because belief “aims at truth”. It must be explained how we are capable of doxastic agency despite that we cannot believe or come to believe at will. On the orthodox ‘causalist’ conception of inference for an inference to occur is for one act of acceptance to cause another in some specifiable “right way”. This conception of inference prevents its advocates from adequately seeing how reasoning could be a means to exercise doxastic agency, as it is natural to think it is. Suppose, for instance, that one reasons and concludes by inferring where one’s inference yields belief in what one infers. Such an inference cannot be performed at will. We cannot infer at will when inference yields belief any more than we can believe or come to believe at will. When it comes to understanding the extent to which one could be exercising agency in such a case the causalist conception of inference suggests that we must look to the causal history of one’s concluding act of acceptance, the nature of the act’s being determined by the way in which it is caused. What results is a picture on which such reasoning as a whole cannot be action. We are at best capable of actions of a kind which lead causally to belief fixation through “mental ballistics”. The causalist account of inference, I argue, is in fact either inadequate or unmotivated. It either fails to accommodate the self-consciousness of inference or is not best placed to play the very explanatory role which it is put forward to play. On the alternative I develop when one infers one’s inference is the conscious event which is one’s act of accepting that which one is inferring. The act’s being an inference is determined, not by the way it is caused, but by the self-knowledge which it constitutively involves. This corrected understanding of inference renders the move from the challenge to the possibility of doxastic agency to the above ballistics picture no longer tempting. It also yields an account of how we are capable of exercising doxastic agency by reasoning despite being unable to believe or come to believe at will. In order to see how such reasoning could amount to the exercise of doxastic agency it needs to be conceived of appropriately. I suggest that paradigm reasoning which potentially amounts the exercise of doxastic agency ought to be conceived of as primarily epistemic agency—agency the aim of which is knowledge. With inference conceived as suggested, I argue, it can be seen how to engage in such reasoning can just be to successfully exercise such agency. (shrink)

Platonists affirm the existence of abstract mathematical objects, and Nominalists deny the existence of abstract mathematical objects. While there are standard arguments in favor of Nominalism, these arguments fail to account for the necessity of Nominalism. Furthermore, these arguments do nothing to explain why Nominalism is true. They only point to certain theoretical vices that might befall the Platonist. The goal of this paper is to formulate and defend a simple, valid argument for the necessity of Nominalism that seeks to (...) precisify the widespread intuition that mathematical objects are somehow ‘spooky’ or ‘mysterious’. (shrink)

Pain asymbolia is a rare condition caused by brain damage, usually in adulthood. Asymbolics feel pain but appear indifferent to it, and indifferent also to visual and verbal threats. How should we make sense of this? Nikola Grahek thinks asymbolics’ pains are abnormal, lacking a component that make normal pains unpleasant and motivating. Colin Klein thinks that what is abnormal is not asymbolics’ pains, but asymbolics: they have a psychological deficit making them unresponsive to unpleasant pain. I argue that an (...) illuminating account requires elements of both views. Asymbolic pains are indeed abnormal, but they are abnormal because asymbolics are. I agree with Klein that asymbolics are incapable of caring about their bodily integrity; but I argue against him that, if this is to explain not only their indifference to visual and verbal threat, but also their indifference to pain, we must do the following: (i) take asymbolics’ lack of bodily care not as an alternative to, but as an explanation of their pains’ missing a component, and (ii) claim that the missing component consists in evaluative content. Asymbolia, I conclude, reveals not only that unpleasant pain is composite, but that its ‘hedomotive component’ is evaluative. (shrink)

In Book I of his Nicomachean Ethics (NE), Aristotle defines happiness, or eudaimonia, in accordance with an argument he makes regarding the distinctive function of human beings. In this paper, I argue that, despite this argument, there are moments in the NE where Aristotle appeals to elements of happiness that don’t follow from the function argument itself. The place of these elements in Aristotle’s account of happiness should, therefore, be a matter of perplexity. For, how can Aristotle appeal to elements (...) of happiness not entailed by his argument for what happiness involves? I will examine two instances that exemplify the sort of appeal to outside elements that I have in mind. The first deals with Aristotle’s reference, in NE, I, 8, to certain goods—ancestry, children, beauty—goods unrelated to man’s function or his fulfillment of it, but nevertheless required for his happiness. The second instance involves pleasure. Aristotle makes various arguments, both in Books I and X of the NE, that tie pleasure to the activity of the soul, and the function argument in turn. However, none of these arguments succeeds in demonstrating that pleasure would necessarily follow from this activity. Taken together then, these two examples demonstrate the extent to which Aristotle’s definition of happiness is more inclusive than his function argument permits. (shrink)

This is a contribution to the symposium on Tim Scanlon’s Being Realistic about Reasons. We have two aims here: First, we ask for more details about Scanlon’s meta-metaphysical view, showing problems with salient clarifications. And second, we raise independent objections to the view – to its explanatory productivity, its distinctness, and the argumentative support it enjoys.

This paper examines the practice of using predictive systems to lengthen the prison sentences of convicted persons when the systems forecast a higher likelihood of re-offense or re-arrest. There has been much critical discussion of technologies used for sentencing, including questions of bias and opacity. However, there hasn’t been a discussion of whether this use of predictive systems makes sense in the first place. We argue that it does not by showing that there is no plausible theory of punishment that (...) supports it. (shrink)

According to dispositionalism about modality, a proposition <p> is possible just in case something has, or some things have, a power or disposition for its truth; and <p> is necessary just in case nothing has a power for its falsity. But are there enough powers to go around? In Yates (2015) I argued that in the case of mathematical truths such as <2+2=4>, nothing has the power to bring about their falsity or their truth, which means they come out both (...) necessary and not possible. Combining this with axiom (T), it is easy to derive a contradiction. I suggested that dispositionalists ought to retreat a little and say that <p> is possible just in case either p, or there is a power to bring it about that p, grounding the possibility of mathematical propositions in their truth rather than in powers. Vetter’s (2015) has the resources to provide a response to my argument, and in her (2018) she explicitly addresses it by arguing for a plenitude of powers, based on the idea that dispositions come in degrees, with necessary properties a limiting case of dispositionality. On this view there is a power for <2+2=4>, without there being a power to bring about its truth. In this paper I argue that Vetter’s case for plenitude does not work. However, I suggest, if we are prepared to accept metaphysical causation, a case can be made that there is indeed a power for <2+2=4>. (shrink)

A number of philosophers endorse, without argument, the view that there’s something it’s like consciously to think that p, which is distinct from what it’s like consciously to think that q. This thesis, if true, would have important consequences for philosophy of mind and cognitive science. In this paper I offer an argument for it, and attempt to induce examples of it in the reader. The argument claims it would be impossible introspectively to distinguish conscious thoughts with respect to their (...) content if there weren’t something it’s like to think them. This argument is defended against several objections. Then I use what I call “minimal pair” experiences—sentences read without and with understanding—to induce in the reader an experience of the kind I claim exists. Further objections are considered and rebutted. (shrink)

Sometimes the philosophical armchair gets bumped by empirical facts. So it is when thinking about pain. For good or ill (good, actually, as we shall see) most of us are intimately acquainted with physical pain, the kind you feel when you stand on a nail or burn your hand. And, from the armchair, it can seem blindingly obvious that pain is essentially unpleasant. There are of course unpleasant experiences that aren’t pains – nausea or itches, for example – but surely (...) there aren’t pains that don’t hurt, pains that are neutral or even pleasurable rather than unpleasant. Surely, indeed, there couldn’t be. For it is part of the very concept of a pain that a pain be unpleasant. Or so it has seemed to many. Yet over recent decades philosophers’ confidence in these putative truisms has been shaken by some fascinating cases from the clinic, the lab, and life. (shrink)

"La struttura delle rivoluzioni scientifiche", dopo più di mezzo secolo dalla sua pubblicazione, è ancora in grado di offrire un contributo alla pratica filosofica? In questo articolo, attraverso i concetti peirceani di Abito, Abduzione e Verità, si propone una lettura pragmaticista del testo di Kuhn che intende rilanciare un fecondo confronto, ancora poco considerato, tra i due filosofi.

This article critically investigates the landscape of contemporary philosophical hermeneutics, especially Gadamerian hermeneutics. This investigation reveals that one of the central trends in recent decades has been to construe hermeneutics as, instead of an ongoing and substantive philosophical research project, rather an amorphous current or nebulous spirit of intellectual life and culture—what this article refers to as the sense of hermeneutics as an attitude. The “effective history” of this characterization of hermeneutics is traced to polemical references to hermeneutics by Alain (...) Badiou and Richard Rorty, which have negatively contributed to the reception of the hermeneutical movement. The article suggests that hermeneutics should aim to be neither a vague sensibility nor, in what ultimately amounts to a reaction against the idea of hermeneutics as an attitude, a rigorous “method” of interpretation, but rather an ongoing philosophical research program. To unpack this suggestion, the article concludes by providing “foundations for a contemporary hermeneutics” with reference to six contributions from promising recent work in hermeneutics. (shrink)

Each new decade brings ‘advances’ in technology that are more capable of collecting, aggregating, organizing, and deploying data about human practices. Where we go, what we buy, what we say online, and the people with whom we connect, are captured with ever more sophistication by governmental and corporate institutions. Data are increasingly being sold to schools to help them ‘manage’ teaching and administration tasks. Of course, at the same time, schools, teachers, and students are generating data that further advances the (...) goals of data aggregators. After some discussion regarding data’s philosophical dimensions, this chapter examines the benefits and drawbacks of surveillance and datafication in present educational contexts. In addition, this chapter raises ethical and pragmatic questions related to how datafication often reshapes or redefines agency, choice, personal relationships, and individuality. In response to some of the ethical qualms raised by these questions, a vision (imaginary) is proposed to help conserve some of the educational values threatened by datafication, including values related to genuine interest, sociality, and transformative, and qualitative experiences. -/- CITATION: Hildebrand, D.L. (2024). What are Data and Who Benefits?. In: Buch, A., Lindberg, Y., Cerratto Pargman, T. (eds) Framing Futures in Postdigital Education. Postdigital Science and Education . Springer, Cham. doi: 10.1007/978-3-031-58622-4_5 -/- . (shrink)

Priority Theory is an increasingly popular view in metaphysics. By seeing metaphysical questions as primarily concerned with what explains what, instead of merely what exists, it promises not only an interesting approach to traditional metaphysical issues but also the resolution of some outstanding disputes. In a recent paper, Louis deRosset argues that Priority Theory isn’t up to the task: Priority Theory is committed to there being explanations that violate a formal constraint on any adequate explanation. This paper critically examines deRosset’s (...) challenge to Priority Theory. We argue that deRosset’s challenge ultimately fails: his proposed constraint on explanation is neither well-motivated nor a general constraint. Nonetheless, lurking behind his criticism is a deep problem for prominent ways of developing Priority Theory, a problem which we develop. (shrink)

Beyond Dordt and ‘De Auxiliis’ explores post-Reformation inter-confessional theological exchange on soteriological topics including predestination, grace, and free choice. These doctrines remained controversial within confessional traditions after the Reformation, as Dominicans and Jesuits and later Calvinists and Arminians argued about these critical issues in the Augustinian theological heritage. Some of those involved in condemning Arminianism at the Synod of Dordt (1618-1619) were inspired by Dominican followers of Thomas Aquinas in Spain who had recently opposed the vigorous defense of free choice (...) by Jesuit Molinists in the Congregatio de auxiliis (1598-1607). This volume, appearing on the 400th anniversary of the closing of the Synod of Dordt, brings together a group of scholars working in fields that only rarely speak to one another to address these theological debates that cross geographical and confessional boundaries. (shrink)

We have a mentalistic view of objects. This is due to the interdependence of folk psychology and folk physics, where these are interconnected by what I call Teleological Commingling. When considering events that don’t involve agents, we naturally default to tracking intentions, goal-directed processes, despite the fact that agents aren’t involved. We have a deep-seated intentionality bias which is the result of the pervasive detection of agency cues, such as order or non-randomness. And this gives rise to the Agentive Worldview: (...) we view nature as a whole as being infused with agency and purpose. Teleological Commingling and the Agentive Worldview it gives rise to are at the core of our conception of objects. I maintain that the ordinary view of material objects is rooted in an implicit, false theory. It should be given no weight in metaphysical debates about the nature of material objects. And this problematizes the central methodological assumption that metaphysical theories of material objects should be beholden to common sense. (shrink)

The essay explores the intersection of the Theory of Mind (T.O.M.) and Artificial Intelligence (AI), emphasizing the potential for AI to emulate cognitive processes fundamental to human social interactions. T.O.M., a concept crucial for understanding and interpreting human behavior through attributed mental states, contrasts with AI's behaviorist approach, which is rooted in data-driven pattern analysis and predictions. By examining foundational insights from cognitive sciences and the operational models of AI, this analysis highlights the potential advancements and implications of integrating T.O.M.-like (...) capabilities into AI systems. The discussion pivots around three critical questions: whether AI should emulate T.O.M. to enhance human interactions if AI can maintain its data-driven model while integrating cognitive processes, and how AI can expand its capabilities in social contexts. The arguments suggest that incorporating T.O.M.-like processes could significantly improve AI's interaction quality without compromising its analytical strengths, pointing towards a future where AI not only predicts but also empathizes, offering more nuanced and culturally aware interactions. This synthesis of cognitive theories and computational strategies advocates for deeper integration of diverse datasets and advanced computing methodologies, aiming to transform AI into a more empathetic and effective participant in human social environments. -/- Keywords: Theory of Mind, Artificial Intelligence, Human-AI Interaction, Cognitive Processes, Data-Driven Analysis. (shrink)

The question of whether Everettian quantum mechanics (EQM) justifies the existence of metaphysical indeterminacy has recently come to the fore. Metaphysical indeterminacy has been argued to emerge from three sources: coherent superpositions, the indefinite number of branches in the quantum multiverse and the nature of these branches. This paper reviews the evidence and concludes that those arguments don’t rely on EQM alone and rest on metaphysical auxiliary assumptions that transcend the physics of EQM. We show how EQM can be ontologically (...) interpreted without positing metaphysical indeterminacy by adopting a deflationary attitude towards branches. Two ways of developing the deflationary view are then proposed: one where branches are eliminated, and another where they are reduced to the universal quantum state. (shrink)

Heterogeneous treatment effects represent a major issue for medicine as they undermine reliable inference and clinical decision-making. To overcome the issue, the current vision of precision and personalized medicine acknowledges the need to control individual variability in response to treatment. In this paper, we argue that gene-treatment-environment interactions (G × T × E) undermine inferences about individual treatment effects from the results of both genomics-based methodologies—such as genome-wide association studies (GWAS) and genome-wide interaction studies (GWIS)—and randomized controlled trials (RCTs). Then, (...) we argue that N-of-1 trials can be a solution to overcome difficulties in handling individual variability in treatment response. Although this type of trial has been suggested as a promising strategy to assess individual treatment effects, it nonetheless has limitations that limit its use in everyday clinical practice. We analyze the existing variability within the designs of N-of-1 trials in terms of a continuum where each design prioritizes epistemic and pragmatic considerations. We then support wider use of the designs located at the pragmatic end of the explanatory-pragmatic continuum. (shrink)

Many philosophers of physics think that physical rates of change, like velocity or acceleration in classical physics, are extrinsic. Many philosophers of mind think that phenomenal properties, which characterize what it’s like to be an agent at a time, are intrinsic. I will argue that these two views can’t both be true. Given that these two views are in tension, we face an explanatory challenge. Why should there be any interesting connection between these physical quantities and consciousness in the first (...) place? In a speculative spirit, I close by developing a panpsychist view which promises to explain this connection in a particularly satisfying way. (shrink)

This paper develops and motivates a unification theory of metaphysical explanation, or as I will call it, Metaphysical Unificationism. The theory’s main inspiration is the unification account of scientific explanation, according to which explanatoriness is a holistic feature of theories that derive a large number of explananda from a meager set of explanantia, using a small number of argument patterns. In developing Metaphysical Unificationism, I will point out that it has a number of interesting consequences. The view offers a novel (...) conception of metaphysical explanation that doesn’t rely on the notion of a “determinative” or “explanatory” relation; it allows us to draw a principled distinction between metaphysical and scientific explanations; it implies that naturalness and fundamentality are distinct but intimately related notions; and perhaps most importantly, it re-establishes the unduly neglected link between explanation and understanding in the metaphysical realm. A number of objections can be raised against the view, but I will argue that none of these is conclusive. The upshot is that Metaphysical Unificationism provides a powerful and hitherto overlooked alternative to extant theories of metaphysical explanation. (shrink)

The paper investigates what type of motivation can be given for adopting a knowledge-based decision theory. KBDT seems to have several advantages over competing theories of rationality. It is commonly argued that this theory would naturally fit with the intuitive idea that being rational is doing what we take to be best given what we know, an idea often supported by appeal to ordinary folk appraisals. Moreover, KBDT seems to strike a perfect balance between the problematic extremes of subjectivist and (...) objectivist decision theory. We argue that these alleged advantages do not stand up to a closer scrutiny: KBDT inherits the same kinds of problems as alternative decision theoretic frameworks but doesn’t retain any of the respective advantages. Moreover, differently from other knowledge-action principles advanced in the literature, KBDT cannot fully explain the intuitive connections between knowledge and rational action. We conclude that the most serious challenge for knowledge-based decision theorists is to provide a substantive rationale for the adoption of such a view. (shrink)

According to some philosophers, a necessary condition of morally permissible punishment is that it communicates deserved censure for the offender’s wrongdoing. The author calls this the Communicative Condition of punishment. The chapter considers whether the use of mandatory crime-preventing neurointerventions is compatible with the Communicative Condition. The author argues that it is not. If we accept the Communicative Condition, it follows that it is impermissible to administer mandatory neurointerventions on offenders as punishment. The author then considers whether it is permissible (...) to offer an offender a neurointervention as a replacement for incarceration or in exchange for a shorter sentence. He notes that this could meet the Communicative Condition, although, somewhat oddly, only in cases where the neurointerventions have harmful effects. (shrink)

This paper is about the principle that success entails ability, which I call Success. I argue the status of Success is highly puzzling: when we focus on past instances of actually successful action, Success is very compelling; but it is in tension with the idea that true ability claims require an action be in the agent's control. I make the above tension precise by considering the logic of ability. I argue Success is appealing because it is classically equivalent to two (...) genuinely valid inferences, which I call Past Success and Can't-Entails-Won't; but also that Success itself has counterexamples. I show how to invalidate Success while validating Past Success and Can't-Entails-Won't by connecting the meaning of ‘can’ to facts about what is settled or open. I define an operator W with features attributed to ‘will’ in the literature on future contingents. I then give a conditional analysis of ability ascriptions stated with W-conditionals, where "S can A" says, roughly, there’s some action available to S such that if S does it, then W(S A). I show this semantics invalidates Success while still explaining its appeal. (shrink)

Abstract:Skepticism about grounding is the view that ground-theoretic concepts shouldn’t be used in meta­physical theorizing. Possible reasons for adopting this attitude are numerous: perhaps grounding is unintelligible; or perhaps it’s never instantiated; or perhaps it’s just too heterogeneous to be theor­­­­­etically useful. Unfortunately, as currently pursued the debate between grounding enthusiasts and skeptics is insufficiently structured. This paper’s purpose is to impose a measure of conceptual rigor on the debate by offering an opinionated taxonomy of views with a reasonable claim (...) to being “skeptical.” I argue that carving up logical space into pro- and anti-grounding views isn’t especially helpful; rather, we should recognize various degrees of ground-theoretic involvement depending on how inflationary our understanding of the theoretical term ‘ground’ is. (shrink)

In this paper, we develop an account of the justification thinkers have for employing certain basic belief-forming methods. The guiding idea is inspired by Reichenbach's work on induction. There are certain projects in which thinkers are rationally required to engage. Thinkers are epistemically justified in employing any belief-forming method such that "if it doesn't work, nothing will" for successfully engaging in such a project. We present a detailed account based on this intuitive thought and address objections to it. We conclude (...) by commenting on the implications that our account may have for other important epistemological issues and debates. (shrink)

A growing literature is premised on the claim that quantum mechanics provides evidence for metaphysical indeterminacy. But does it? None of the currently fashionable realist interpretations involve fundamental indeterminacy and the ‘standard interpretation’, to the extent that it can be made out, doesn't require indeterminacy either.

“I don’t want to create painful shoes, but it is not my job to create something comfortable.” – Christian Louboutin. (in Alexander, 2012) Pain is an essential part of the grooming process, and that...

Many philosophers embrace grounding, supposedly a central notion of metaphysics. Grounding is widely assumed to be irreflexive, but recently a number of authors have questioned this assumption: according to them, it is at least possible that some facts ground themselves. The primary purpose of this paper is to problematize the notion of self-grounding through the theoretical roles usually assigned to grounding. The literature typically characterizes grounding as at least playing two central theoretical roles: a structuring role and an explanatory role. (...) Once we carefully spell out what playing these roles includes, however, we find that any notion of grounding that isn’t irreflexive fails to play these roles when they are interpreted narrowly, and is redundant for playing them when they are interpreted more broadly. The upshot is that no useful notion of grounding can allow a fact to ground itself. (shrink)

The aim of this paper is to create dialectical space for a hitherto under-discussed option in the philosophy of conspiracy theories. The extant literature on the topic almost exclusively assumes that conspiracy theories are a type of explanation. The typical mental attitude towards explanations is belief, a representational attitude that can be assessed as true, false, warranted or unwarranted. I call models based on this assumption alethic models. Alethic models can’t pick out conspiracy theories as a distinct class of mental (...) attitudes without latching onto their negative epistemic properties. The extant literature therefore finds itself in an unfortunate situation. It either has to presume that conspiracy theories are epistemically defective in general (generalism). Or it has to deny that conspiracy theories are a distinct class of mental attitudes. Conspiracy theories are then nothing more than theories, theories about conspiracies, and should be assessed on a case-by-case basis (particularism). Instead, this paper motivates the research program of narrative models. According to narrative models, conspiracy theories are first and foremost stories – structured fictions. And their relevant mental attitudes are the attitudes of fiction – make-believe and imagination. Fictions are not subjects to epistemic norms. They are neither rational nor irrational. Narrative models can therefore pick out conspiracy theories as a distinct class of mental attitudes without labeling them as defective in general. In addition, they are able to explain certain features of conspiracy discourse particularly well, and they offer new perspectives on the popularity of conspiracy theories and the means of intervention we have at our disposal. (shrink)

The idea that incompatibilism is intuitive is one of the key motivators for incompatibilism. Not surprisingly, then philosophers who defend incompatibilism often claim that incompatibilism is the natural, commonsense view about free will and moral responsibility (e.g., Pereboom 2001, Kane Journal of Philosophy 96:217–240 1999, Strawson 1986). And a number of recent studies find that people give apparently incompatibilist responses in vignette studies. When participants are presented with a description of a causal deterministic universe, they tend to deny that people (...) are morally responsible in that universe. Although this suggests that people are intuitive incompatibilists, Eddy Nahmias and Dylan Murray, in a recent series of important papers, have developed an important challenge to this interpretation. They argue that people confuse determinism with bypassing, the idea that one’s mental states lack causal efficacy. Murray and Nahmias present new experiments that seem to confirm the bypassing hypothesis. In this paper, we use structural equation modeling to re-examine the issue. We find support instead for an incompatibilist explanation of the bypassing results, i.e., incompatibilist judgments seem to cause bypassing judgments. We hypothesize that this phenomenon occurs because people think of decisions as essentially indeterministic; thus, when confronted with a description of determinism they tend to think that decisions do not even occur. We provide evidence for this in three subsequent studies which show that many participants deny that people make decisions in a deterministic universe; by contrast, most participants tend to allow that people add numbers in a deterministic universe. Together, these studies suggest that bypassing results don’t reflect a confusion, but rather the depth of the incompatibilist intuition. (shrink)

Revisionary ontologies seem to go against our common sense convictions about which material objects exist. These views face the so-called Problem of Reasonableness: they have to explain why reasonable people don’t seem to accept the true ontology. Most approaches to this problem treat the mismatch between the ontological truth and ordinary belief as superficial or not even real. By contrast, I propose what I call the “uncompromising solution”. First, I argue that our beliefs about material objects were influenced by evolutionary (...) forces that were independent of the ontological truth. Second, I draw an analogy between the Problem of Reasonableness and the New Evil Demon Problem and argue that the revisionary ontologist can always find a positive epistemic status to characterize ordinary people’s beliefs about material objects. Finally, I address the worry that the evolutionary component of my story also threatens to undermine the best arguments for revisionary ontologies. (shrink)

Tradução para o português de "Uma espécie de história de minha vida" (A kind of history of my life), ou Carta a um médico (A Letter to a Physician), uma carta escrita por Hume (1711-1776), endereçada em março ou abril de 1734 a um médico não identificado (segundo Norton provavelmente John Arbuthnot ou George Cheyne), na qual Hume pede alguns conselhos para continuar com o seu trabalho filosófico. O título atual é extraído do primeiro parágrafo.A carta foi escrita em 1734, (...) um pouco antes de Hume viajar para Bristol, onde, “forçado a fazer uma rápida incursão em uma vida mais ativa”, conforme relata em sua autobiografia Minha vida, buscou empregar-se no comércio. A importância dessa carta reside no seu caráter autobiográfico e nos comentários que Hume faz sobre seu projeto filosófico. A carta foi publicada originalmente em Life and correspondence of David Hume, John Hill Burton(Ed.), Edinburgh 1846, v. 1, p. 30-39; ela foi reproduzida em The Letters of David Hume. Grey, J. Y. T. (ed.) Oxford: Clarendon Press, 1932, 2v; v.1, n.3, p. 12-18, e pode ser encontrada também em The Cambridge companion to Hume, David Fate Norton, Jacqueline Taylor (ed.) 2 ed. Cambridge University Press, 2009, p. 515-522. Para essa tradução consultamos o texto original conforme apresentado nas duas últimas edições aqui mencionadas. (shrink)

Most of our best scientific descriptions of the world employ rates of change of some continuous quantity with respect to some other continuous quantity. For instance, in classical physics we arrive at a particle’s velocity by taking the time-derivative of its position, and we arrive at a particle’s acceleration by taking the time-derivative of its velocity. Because rates of change are defined in terms of other continuous quantities, most think that facts about some rate of change obtain in virtue of (...) facts about those other continuous quantities. For example, on this view facts about a particle’s velocity at a time obtain in virtue of facts about how that particle’s position is changing at that time. In this paper we raise a puzzle for this orthodox reductionist account of rate of change quantities and evaluate some possible replies. We don’t decisively come down in favour of one reply over the others, though we say some things to support taking our puzzle to cast doubt on the standard view that spacetime is continuous. (shrink)

Christian apologists, like Willian Lane Craig and Stephen T. Davis, argue that belief in Jesus’ resurrection is reasonable because it provides the best explanation of the available evidence. In this article, I refute that thesis. To do so, I lay out how the logic of inference to the best explanation (IBE) operates, including what good explanations must be and do by definition, and then apply IBE to the issue at hand. Multiple explanations—including (what I will call) The Resurrection Hypothesis, The (...) Lie Hypothesis, The Coma Hypothesis, The Imposter Hypothesis, and The Legend Hypothesis—will be considered. While I will not attempt to rank them all from worst to best, what I will reveal is how and why The Legend Hypothesis is unquestionably the best explanation, and The Resurrection Hypothesis is undeniably the worst. Consequently, not only is Craig and Davis’ conclusion mistaken, but belief in the literal resurrection of Jesus is irrational. In presenting this argument, I do not take myself to be breaking new ground; Robert Cavin and Carlos Colombetti have already presented a Bayesian refutation of Craig and Davis’ arguments. But I do take myself to be presenting an argument that the average person (and philosopher) can follow. It is my goal for the average person (and philosopher) to be able to clearly understand how and why the hypothesis “God supernaturally raised Jesus from the dead” fails utterly as an explanation of the evidence that Christian apologist cite for Jesus’ resurrection. (shrink)

People suffering from severe monothematic delusions, such as Capgras, Fregoli, or Cotard patients, regularly assert extraordinary and unlikely things. For example, some say that their loved ones have been replaced by impostors. A popular view in philosophy and cognitive science is that such monothematic delusions aren't beliefs because they don't guide behaviour and affect in the way that beliefs do. Or, if they are beliefs, they are somehow anomalous, atypical, or marginal beliefs. We present evidence from five studies that folk (...) psychology unambiguously views monothematic delusions as stereotypical beliefs. This calls into question widespread assumptions in the professional literature about belief's stereotypical functional profile. We also show that folk psychology views delusional patients as holding contradictory beliefs. And we show that frequent assertion is a powerful cue to belief ascription, more powerful than even a robust and consistent track record of non-verbal behaviour. (shrink)